Radiesse® dermal filler is made of unique calcium-based microspheres that are suspended in a water-based gel and injected into the skin. Radiesse® is a safe and effective treatment for filling and correcting smile lines, nasolabial folds and wrinkles around the nose and mouth. Radiesse® dermal filler can also augment cheeks and fill marionette lines. Radiesse® filler works below the skin’s surface to stimulate the body to produce new collagen. This unique response provides immediate, visible improvement of folds and wrinkles, and provides long-lasting and beautiful results. In many patients, the results may last for a year or more.